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KMID : 0377220010260010044
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Medical Journal of Chosun Univercity
2001 Volume.26 No. 1 p.44 ~ p.48
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Proliferation index and Apoptosis Rate in Brain Glioma
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Kim Young-Chul
Park Myung-Soo
Yang Jeong-Won
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Abstract
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Background and Objectives : Proliferating cell nuclear antigen (PCNA) correlated with the rates of cellular proliferation and DNA synthesis. It is 36-kD nuclear acidic protein, and present throughout the cell cycle. Apoptosis also correlates with tumor development. The purpose of this study is the investigate of the relationshipal PCNA and apoptotic rates in gliomas.
Materials and Methods : This study analyzed 50 paraffin-embedded glioma, including 15 cases of low grade, 20 cases of high grade, and 15 cases of maligant glioma (glioblastoma multiforme), for the status of proliferating index and apoptotic rates. The evaluation of immunostaining result was based on the percentage of positive neoplastic cells.
Results : Average positive cell rates of PCNA were 14.3%, 45.2% and 62.0% in low grade glioma, high grade glioma and glioblastoma multiforme, respectively. Apoptotic rates were 52.3%, 41.0% and 25.2% in low grade glioma, high grade glioma and glioblastoma multiforme, respectively.
Conclusion : This results suggest that PCNA positivity was correlated with histologic grade of glial tumors. And high grade glioma and glioblastoma multiforme showed higher positive cell rate rather than low grade glioma. Apoptotic rates were higher in low grade glioma than high grade or malignant glioma. So, the PCNA and the apoptosis rates is great useful parameter for a patient’ s prognosis.
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KEYWORD
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Glioma, PCNA, Apoptosis
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